Difference between revisions of "Hypericum-amitriptyline"
From Psychiatrienet
(Created page with '{{ Drugswitch | from = hypericum | to = amitriptyline | stop = * Administration of hypericum can be stopped abruptly. | start = * '''Day 1-7:''' a wash-out period of one we...') |
|||
| Line 6: | Line 6: | ||
| start = | | start = | ||
* '''Day 1-7:''' a wash-out period of one week is necessary. | * '''Day 1-7:''' a wash-out period of one week is necessary. | ||
| − | + | * '''Day 8:''' start administration of amitriptyline in a dosage of 25 mg/day. | |
* If necessary, increase dosage of agomelatine to 50 mg/day. | * If necessary, increase dosage of agomelatine to 50 mg/day. | ||
* Start low, go slow. | * Start low, go slow. | ||
| info = | | info = | ||
* Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericum.}} | * Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericum.}} | ||
Revision as of 13:22, 7 May 2009
| ||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||
Switch medication from hypericum to amitriptyline.[1] [2]
Stop hypericum - Administration of hypericum can be stopped abruptly.
Start amitriptyline- Day 1-7: a wash-out period of one week is necessary.
- Day 8: start administration of amitriptyline in a dosage of 25 mg/day.
- If necessary, increase dosage of agomelatine to 50 mg/day.
- Start low, go slow.
More information- Hypericum slows the metabolism of amitriptyline via CYP3A4. This effect may persist up to two weeks after stopping hypericum.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
