Difference between revisions of "Paroxetine-bupropion"
From Psychiatrienet
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* '''Day 15:''' if necessary increase bupropion to 300 mg/day. | * '''Day 15:''' if necessary increase bupropion to 300 mg/day. | ||
| info = | | info = | ||
| − | * | + | * An extra reduction week to paroxetine 2,5 mg/day sometimes is necessary. |
* Low doses of paroxetine can be given by a paroxetine-solution. | * Low doses of paroxetine can be given by a paroxetine-solution. | ||
}} | }} | ||
Revision as of 11:03, 27 July 2009
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Switch medication from paroxetine to bupropion.[1] [2]
Stop paroxetine - Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
Start bupropion- Day 1: simultaneously start administration of bupropion is a normal dosage of 150 mg/day.
- Day 15: if necessary increase bupropion to 300 mg/day.
More information- An extra reduction week to paroxetine 2,5 mg/day sometimes is necessary.
- Low doses of paroxetine can be given by a paroxetine-solution.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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