Difference between revisions of "Mianserine-escitalopram"
From Psychiatrienet
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| − | + | {{Drugswitch | |
| + | | from = mianserine | ||
| + | | to = escitalopram | ||
| + | | stop = | ||
| + | * '''Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day. | ||
| + | * '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day. | ||
| + | * '''Day 8:''' stop administration of mianserine. | ||
| + | | start = | ||
| + | * '''Day 1:''' simultaneously start escitalopram in a normal dosage of 10 mg/day. | ||
| + | * If necessary, increase the dosage of escitalopram. | ||
| + | | info = | ||
| + | * Caution with this switch is necessary, because escitalopram slows the metabolism of mianserine via CYP2D6. | ||
| + | }} | ||
Revision as of 23:40, 4 March 2010
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Switch medication from mianserine to escitalopram.[1] [2]
Stop mianserine - Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
- Day 8: stop administration of mianserine.
Start escitalopram- Day 1: simultaneously start escitalopram in a normal dosage of 10 mg/day.
- If necessary, increase the dosage of escitalopram.
More information- Caution with this switch is necessary, because escitalopram slows the metabolism of mianserine via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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