Difference between revisions of "Tranylcypromine-escitalopram"
From Psychiatrienet
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{{Drugswitch | {{Drugswitch | ||
| from = tranylcypromine | | from = tranylcypromine | ||
| − | | to = | + | | to = escitalopram |
| stop = | | stop = | ||
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week. | * Gradually decrease the dosage of tranylcypromine with 10-20 mg/week. | ||
Revision as of 23:52, 4 March 2010
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Switch medication from tranylcypromine to escitalopram.[1] [2]
Stop tranylcypromine - Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
- When a dosage of 10 mg/day is reached, stop administration.
Start escitalopram- Day 1-14: a wash-out period of two weeks is necessary.
- Day 15: start escitalopram after this period in a low dosage of 5 mg/day.
More information- Occurrence of the serotonin syndrome is possible without the wash-out period.
- The wash-out period is necessary for the MAO enzymes to restore their function.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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