Difference between revisions of "Bupropion-paroxetine"
From Psychiatrienet
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* When a dosage of 150 mg/day is reached, stop administration. | * When a dosage of 150 mg/day is reached, stop administration. | ||
| start = | | start = | ||
| − | * | + | * '''Day 1-7:''' a wash-out period of at least one week is necessary. |
| − | * | + | * '''Day 8:''' start paroxetine the next day in low dosage of 10 mg/day. |
| info = | | info = | ||
* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. | * By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. | ||
* Bupropion slows the metabolismof paroxetine by CYP2D6.}} | * Bupropion slows the metabolismof paroxetine by CYP2D6.}} | ||
Revision as of 12:14, 4 May 2009
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Switch medication from bupropion to paroxetine.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start paroxetine- Day 1-7: a wash-out period of at least one week is necessary.
- Day 8: start paroxetine the next day in low dosage of 10 mg/day.
More information- By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
- Bupropion slows the metabolismof paroxetine by CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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