Difference between revisions of "Tranylcypromine-trazodone"
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* Occurrence of the serotonin syndrome is possible without a wash-out period, so caution is necessary. | * Occurrence of the serotonin syndrome is possible without a wash-out period, so caution is necessary. | ||
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| − | * The wash-out period is necessary for the MAO enzymes to restore their function.}} | + | * The wash-out period is necessary for the MAO enzymes to restore their function. |
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Revision as of 10:09, 7 October 2015
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Switch medication from tranylcypromine to trazodone.[1] [2]
Stop tranylcypromine - Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
- Day 0: When a dosage of 10 mg/day is reached, stop administration.
Start trazodone- Day 1-14: a wash-out period of two weeks is necessary.
- Day 15: start trazodone in dosage of 100-150 mg/day.
- If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
Cave- Occurrence of the serotonin syndrome is possible without a wash-out period, so caution is necessary.
More information- The wash-out period is necessary for the MAO enzymes to restore their function.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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