Difference between revisions of "Bupropion-trazodone"
From Psychiatrienet
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* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually. | * Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually. | ||
* Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6. | * Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6. | ||
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Revision as of 13:59, 7 October 2015
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Switch medication from bupropion to trazodone.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/day.
- When a dosage of 150 mg/day is reached, stop administration.
Start trazodone- Start trazodone the same day in a normal dosage of 100-150 mg/day.
More information- Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
- Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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