Difference between revisions of "Paroxetine-duloxetine"
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Revision as of 14:49, 28 October 2015
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Switch medication from paroxetine to duloxetine.[1] [2]
Stop paroxetine - Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
- Day 8: stop administration of paroxetine.
Start duloxetine- No wash-out period is needed.
- Day 9: start duloxetine the next day in normal dosage of 60 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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