Difference between revisions of "Amitriptyline-bupropion"
From Psychiatrienet
| Line 5: | Line 5: | ||
{{stopAmitriptyline1}} | {{stopAmitriptyline1}} | ||
| start = | | start = | ||
| − | * '''Day | + | * '''Day 8:''' start administration of bupropion in a dosage of 150 mg/day. |
| info = | | info = | ||
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline. | * Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline. | ||
Latest revision as of 15:55, 28 October 2015
| ||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||
Switch medication from amitriptyline to bupropion.[1] [2]
Stop amitriptyline - Before day 1: gradually reduce dosage of amitriptyline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
- Day 1: reduce dosage of amitriptyline to 50 mg/day.
- Day 8: reduce dosage of amitriptyline to 25 mg/day.
- Day 15: stop administration of amitriptyline.
Start bupropion- Day 8: start administration of bupropion in a dosage of 150 mg/day.
More information- Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
- The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
