Difference between revisions of "Trazodone-imipramine"
From Psychiatrienet
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Revision as of 13:12, 4 November 2015
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Switch medication from trazodone to imipramine.[1] [2]
Stop trazodone - Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 100 mg/day.
- Day 4: stop administration of trazodone.
Start imipramineNo wash-out period is needed.
- Day 1: simultaneously start administration of imipramine in a dosage of 25-50 mg/day.
- Day 8: stop administration of trazodone and continue administration of imipramine in a dosage of 50-75 mg/day.
- Start low, go slow.
More information- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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