Difference between revisions of "Amitriptyline-duloxetine"
From Psychiatrienet
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{{Drugswitch | {{Drugswitch | ||
| from = amitriptyline | | from = amitriptyline | ||
| − | | to = | + | | to = duloxetine |
| stop = | | stop = | ||
{{TCAdecrease25p3d}} | {{TCAdecrease25p3d}} | ||
Revision as of 10:44, 30 June 2023
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Switch medication from amitriptyline to duloxetine.[1] [2]
Stop amitriptyline - Day 1: Decrease with about 25% of the original dose per 3 days.
Start duloxetine- Day 1: Start with 50% of the target dose
- Day 8: Increase dose to 100% of the target dose
- Day 9 and after: Gradually increase dose as necessary
More information- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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