Template:HypericumInfo

• Hypericum induces enzymes of the CYP P-450 type and P-gp type.
• Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
• Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.
• The T1/2 of hypericum is 19 - 37 hour.

Wurglics M, Schubert-Zsilavecz M.Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.

KNMP; Informatorium Medicamentorum 2023; Monografie "hypericum" (Dutch)