Amitriptyline-agomelatine
From Psychiatrienet
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Switch medication from amitriptyline to agomelatine.[1] [2]
Stop amitriptyline - Before day 1: gradually reduce dosage of amitriptyline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
- Day 1: reduce dosage of amitriptyline to 50 mg/day.
- Day 8: reduce dosage of amitriptyline to 25 mg/day.
- Day 15: stop administration of amitriptyline.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 15: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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