Nortriptyline-citalopram

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Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from nortriptyline to citalopram.[1] [2]

Nietinrijdenbord.png Stop nortriptyline
  • Before day 0: gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.
  • Day 1: reduce dosage of nortriptyline to 50 mg/day.
  • Day 3: reduce dosage of nortriptyline to 25 mg/day.
Eenrichtingbord.png Start citalopram
  • Day 1: simultaneously start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
  • Day 8: stop administration of nortriptyline and continue administration of citalopram/escitalopram.
Infobord.png More information
  • Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes nortriptyline.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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