Hypericum-agomelatine

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Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from hypericum to agomelatine.[1] [2]

Nietinrijdenbord.png Stop hypericum
  • Day 1: Stop hypericum.
  • The administration of hypericum can be stopped abruptly. Induction of CYP enzymes will last at least 14 more days.
Eenrichtingbord.png Start agomelatine
  • Day 2: Start administration of agomelatine in a dosage of 25 mg/day.
  • If necessary, increase dosage of agomelatine to 50 mg/day.
Infobord.png More information
  • No severe interactions are known.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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