Fluoxetine-moclobemide

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Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide

Switch medication from fluoxetine to moclobemide.[1] [2]

Nietinrijdenbord.png Stop fluoxetine
  • Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
  • When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start moclobemide

Caution is necessary.

  • Day 1-28: a wash-out period of four weeks is necessary.
  • Day 29: start moclobemide the next day in a normal dosage of 300 mg/day.
Infobord.png More information
  • A switch from fluoxetine to moclobemide is not obvious, given the necessary prolonged wash-out period in this case.
  • Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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