Fluoxetine-moclobemide
From Psychiatrienet
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Switch medication from fluoxetine to moclobemide.[1] [2]
Stop fluoxetine - Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- When a dosage of 20 mg/day is reached, stop administration.
Start moclobemideCaution is necessary.
- Day 1-28: a wash-out period of four weeks is necessary.
- Day 29: start moclobemide the next day in a normal dosage of 300 mg/day.
More information- A switch from fluoxetine to moclobemide is not obvious, given the necessary prolonged wash-out period in this case.
- Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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