Citalopram-clomipramine
From Psychiatrienet
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Switch medication from citalopram to clomipramine.[1] [2]
Stop citalopram - Day 0: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
- Day 1: reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day.
- Day 8: stop administration of citalopram/escitalopram.
Start clomipramine- Day 8: no wash-out period is needed. Start administration of clomipramine in a low dosage of 25-50 mg/day.
- Start low, go slow!
Cave- Occurrence of serotonin syndrome is possible when a high dosage of clomipramine is administrated without a wash-out period.
More information- The same applies to escitalopram.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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