Haloperidol LA-Paliperidone LA
From Psychiatrienet
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Switch medication from Haloperidol_LA to Paliperidone_LA.[4] [5]
Stop Haloperidol_LA - Day 1: Last depot injection
Start Paliperidone_LA- Start depot according to general dosing advice on the day you normally would have injected the former depot.
- Testing for acceptance and possible allergic reactions in a low dose can be carried out earlier.
Paliperidone palmitate is since spring 2011 approved by EMEA: therefore this switch is under construction.
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[6]
— Haloperidol_LA — Paliperidone_LA
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N05AD01
- ↑ 2.0 2.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ 3.0 3.1 Farmacotherapeutisch Kompas; Inleidende Tekst Antipsychotica (dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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