Vortioxetine-moclobemide
From Psychiatrienet
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Switch medication from vortioxetine to moclobemide.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 7: stop administration of vortioxetine.
Start moclobemide- Day 8-22: a wash-out period of 2 weeks is necessary.
- Day 23: start administration of moclobemide in normal dosage of 300 mg/day.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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