Maprotiline-clomipramine

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Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from maprotiline to clomipramine.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Gradually reduce dosage of maprotiline to a maximum of 25-75 mg/day.
  • When a dosage of 25-75 mg/day is reached, stop administration.
Eenrichtingbord.png Start clomipramine
  • No wash-out period is needed.
  • Start administration of clomipramine the next day in a dosage of 75 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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