Hypericum-amitriptyline
From Psychiatrienet
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Switch medication from hypericum to amitriptyline.[1] [2]
Stop hypericum - Day 1: Stop hypericum.
- The administration of hypericum can be stopped abruptly. Induction of CYP enzymes will last at least 14 more days.
Start amitriptyline- Day 1: Increase with about 25% of target dose per 3 days.
More information- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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