Venlafaxine-amitriptyline
From Psychiatrienet
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Switch medication from venlafaxine to amitriptyline.[1] [2]
Stop venlafaxine - Day 1-14: gradually reduce dosage of venlafaxine to a maximum of 37,5 mg or 75 mg (slow release)/ day.
- Day 15: stop administration of venlafaxine
Start amitriptyline- Day 15: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
- Day 22: continue administration of amitriptyline in a dosage of 50 mg/day.
More information- “Start low, go slow” for amitriptyline, and caution with this switch is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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