Combining-Valproic acid-Olanzapine
From Psychiatrienet
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Adding olanzapine to valproic acid.
General information- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start olanzapine- Start olanzapine according to the general dosing advice. Monitoring of the liver function every 3 to 4 months during the first year of treatment with either olanzapine or valproic acid is recommended.[5]
Cave- Concurrent use of olanzapine and valproic acid may potentiate the risk of hepatotoxicity.[5]
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas; Toxicologie (dutch)
Cite error: Invalid
<ref>tag; name "ftktox" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas - valproinezuur (dutch)
- ↑ 3.0 3.1 3.2 3.3 3.4 KNMP; Informatorium Medicamentorum 2023; Monografie "valproaat" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ 5.0 5.1 Interactions between olanzapine and valproic acid on drugs.com
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