Trazodone-vortioxetine
From Psychiatrienet
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Switch medication from trazodone to vortioxetine.[1] [2]
Stop trazodone - Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce the dosage of trazodone to 75-100 mg/day.
- Day 8: when a dosage of 75 mg/day is reached, stop administration
Start vortioxetine- A wash-out period is not necessary.
- Day 8: start administration of vortioxetine in a normal dosage of 10 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.
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