Fluoxetine-doxepine

{{Drugswitch | from = fluoxetine | to = doxepin | stop =

• Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
• Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.

| start = Caution is necessary for at least four weeks.

• Day 2: start administration of doxepin in a low dosage of 25 mg/day.
• Day 15: increase dosage of doxepin to 50 mg/day.
• Day 29: increase dosage of doxepin to 75 mg/day.

|info =

• Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6.
• Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
• Start low, go slow for doxepin.