Chlorpromazine-Partial agonist
From Psychiatrienet
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Switch medication from Chlorpromazine to Partial agonist.[1]
[2]
Partial agonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial agonist' group from anotherdrug should be read as partial agonist-anotherdrug. Similarly, a switch from a member of the 'partial agonist' group to anotherdrug should be read as anotherdrug-partial agonist.
Stop Chlorpromazine - Week 1: approx. 75% of initial dose
- Week 2: approx. 50% of initial dose
- Week 3: approx. 25% of initial dose
- Week 4: approx. 12,5% of initial dose
- Day 28: stop
Start Partial agonist- Day 1-3: start 50% of target dose
- Day 4-7: target dose
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
— Chlorpromazine — Partial agonist
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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