Paliperidone ER-Penfluridol

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* This switch is intended for paliperidone long acting (Xeplion®, 30 days)

Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone
Penfluridol
Type Antipsychotic
Group Atypical AP
links
PubMed Penfluridol
Wikipedia Penfluridol

Switch medication from Paliperidone LA to Penfluridol.[1] [2]

Nietinrijdenbord.png Stop Paliperidone LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Penfluridol
  • Week 3: start with 10 mg
  • Week 4: increase dose to 20 mg
  • Week 5 and further: adjust dose according to clinical presentation
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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