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Adding olanzapine to carbamazepine.
General information- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
Start olanzapine- Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. [6][7]
- Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. [8][9]
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- ↑ 2.0 2.1 Farmacotherapeutisch Kompas; Toxicologie (dutch)
Cite error: Invalid
<ref>tag; name "ftktox" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
- ↑ 4.0 4.1 4.2 4.3 4.4 KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43
- ↑ Interactions between carbamazepine and olanzapine on drugs.com
- ↑ Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
- ↑ Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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