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Adding olanzapine to quetiapine.
General information- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start olanzapine- Start olanzapine according to the general dosing advice.
Cave- Agents with anticholinergic properties may have additive effects when used in combination. [4]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 4.0 4.1 Drugs.com quetiapine-fumarate Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
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