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Adding quetiapine to risperidone.
General information- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
Start quetiapine- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Cave- Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. [6]
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 6.0 6.1 Drugs.com quetiapine-fumarate Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content
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