Vortioxetine-fluoxetine

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• Day 1: Decrease with about 25% of the original dose per 3 days.

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• Day 6 and after: At approximately 50-25% of the original vortioxetine dose start fluoxetine at 100% of the target dose.
• After 3 weeks: If necessary, gradually increase dosage of fluoxetine.

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• Safe target dose fluoxetine = 20 mg
• Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong), which metabolizes vortioxetine