Fluvoxamine-agomelatine
From Psychiatrienet
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Switch medication from fluvoxamine to agomelatine.[1] [2]
Stop fluvoxamine 
Start agomelatine- Day 1-7: a wash-out period of one week is necessary.
- Day 8: start administration of agomelatine after this period in a dosage of 25 mg/day.
- If necessary, the dosage of agomelatine can be increased to 50 mg/day.
More information- Fluvoxamine stops the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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