Olanzapine-Zuclopenthixol MA
From Psychiatrienet
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Switch medication from Olanzapine to Zuclopenthixol_MA.[4] [5]
Stop Olanzapine - Stop or reduce drug, depending on symptomatology and (expected) adverse reactions.
- The effects of both drugs will be superimposed for several days.
Start Zuclopenthixol_MA- Day 1: Start drug according general dosing advice.
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[6]
- Zuclopenthixol_MA = Zuclopenthixol acetate [7]
- ↑ 1.0 1.1 1.2 1.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
- ↑ SPC Zuclopenthixol acetate
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