Combining-Risperidone-Olanzapine
From Psychiatrienet
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Adding olanzapine to risperidone.
General information- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- There is no evidence published related to this drug combination recently. The combination will also have additive side effects.
Start olanzapine- Start olanzapine according to the general dosing advice.
Cave- Agents with anticholinergic properties may have additive effects when used in combination. [6]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Interactions between risperidone and olanzapine on drugs.com
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