Moclobemide-trazodone
From Psychiatrienet
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Switch medication from moclobemide to trazodone.[1] [2]
Stop moclobemide - Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
- Day 1: reduce the dosage of moclobemide to 150 mg/day.
- Day 8: stop administration of moclobemide.
Start trazodone- Day 9: start administration of trazodone in a dosage of 100 mg/day.
- Day 16: if necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
More information- Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
- A wash-out period of is not necessary.
- Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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