Amitriptyline-bupropion
From Psychiatrienet
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Switch medication from amitriptyline to bupropion.[1] [2]
Stop amitriptyline - Day 0: gradually reduce dosage of doxepin to a maximum of 100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-3: reduce dosage of doxepin to 50 mg/day.
- Day 4-7: reduce dosage of doxepin to 25 mg/day.
- Day 8: stop administration of doxepin.
Start bupropion- Day 1: simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of amitriptyline according to the scheme above.
- Day 8: stop administration of amitriptyline and continue administration of bupropion only in a dosage of 300 mg/day.
More information- Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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