Vortioxetine-agomelatine
From Psychiatrienet
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Switch medication from Vortioxetine to agomelatine.[1] [2]
Stop Vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start agomelatine- Day 9: start administration of agomelatine in a dosage of 25 mg/day.
- Day 23: if necessary, increase dosage of agomelatine to 50 mg/day.[3]
More information- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
- ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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