SwitchAntipsychotics

Switching Antipsychotics

To see the consequences of a switch between antipsychotics click in the crosstable below: the switch is made "from" (vertical) "to" (horizontal).
During switching: don't reduce dose of other anticholinergic drugs; consider adding oxazepam. Read: General considerations concerning switching antipsychotics.

Rest AP = Chlorprothixene, Flupentixol, Loxapine, Paliperidone, Pericyazine, Perphenazine,Promazine, Trifluoperazine, Zuclopentixol.

Partial antagonist new = Aripiprazole, Brexpiprazole, Cariprazine.

↓ from	to →	Am	Ch	Cp	Hp	Lu	Ol	Pa	Pi	Qu	Rd	Sd	Sr	Zi	RA	Da	Df	Di	Dh	Do	Dp	Dr	Dz	Mz
Am	Amisulpride	—	AmCh	AmCp	AmHp	AmLu	AmOl	AmPa	AmPi	AmQu	AmRd	AmSd	AmSr	AmZi	AmRA	—	—	—	—	—	—	—	—	AmMz
Ch	Chlorpromazine	ChAm	—	ChCp	ChHp	ChLu	ChOl	ChPa	ChPi	ChQu	ChRd	ChSd	ChSr	ChZi	ChRA	—	—	—	—	—	—	—	—	ChMz
Cp	Clozapine	CpAm	CpCh	—	CpHp	CpLu	CpOl	CpPa	CpPi	CpQu	CpRd	CpSd	CpSr	CpZi	CpRA	—	—	—	CpDh	—	—	—	—	CpMz
Hp	Haloperidol	HpAm	HpCh	HpCp	—	HpLu	HpOl	HpPa	HpPi	HpQu	HpRd	HpSd	HpSr	HpZi	HpRA	—	—	—	—	—	—	—	—	HpMz
Lu	Lurasidone	LuAm	LuCh	LuCp	LuHp	—	LuOl	LuPa	LuPi	LuQu	LuRd	LuSd	LuSr	LuZi	LuRA	—	—	—	—	LuDo	—	—	—	LuMz
Ol	Olanzapine	OlAm	OlCh	OlCp	OlHp	OlLu	—	OlPa	OlPi	OlQu	OlRd	OlSd	OlSr	OlZi	OlRA	—	—	—	—	—	OlDp	OlDr	—	OlMz
Pa	Partial antagonist	PaAm	PaCh	PaCp	PaHp	PaLu	PaOl	PaPa	PaPi	PaQu	PaRd	PaSd	PaSr	PaZi	PaRA	PaDa	—	—	—	—	—	—	—	PaMz
Pi	Pimozide	PiAm	PiCh	PiCp	PiHp	PiLu	PiOl	PiPa	—	PiQu	PiRd	PiSd	PiSr	PiZi	PiRA	—	—	—	—	—	—	—	—	PiMz
Qu	Quetiapine	QuAm	QuCh	QuCp	QuHp	QuLu	QuOl	QuPa	QuPi	—	QuRd	QuSd	QuSr	QuZi	QuRA	—	—	—	—	—	—	—	—	QuMz
Rd	Risperidone	RdAm	RdCh	RdCp	RdHp	RdLu	RdOl	RdPa	RdPi	RdQu	—	RdSd	RdSr	RdZi	RdRA	—	—	—	—	—	—	—	—	RdMz
Sd	Sertindole	SdAm	SdCh	SdCp	SdHp	SdLu	SdOl	SdPa	SdPi	SdQu	SdRd	—	SdSr	SdZi	SdRA	—	—	—	—	—	SdDp	SdDr	—	SdMz
Sr	Sulpiride	SrAm	SrCh	SrCp	SrHp	SrLu	SrOl	SrPa	SrPi	SrQu	SrRd	SrSd	—	SrZi	SrRA	—	—	—	—	—	—	—	—	SrMz
Zi	Ziprasidone	ZiAm	ZiCh	ZiCp	ZiHp	ZiLu	ZiOl	ZiPa	ZiPi	ZiQu	ZiRd	ZiSd	ZiSr	—	ZiRA	—	—	—	—	—	—	—	—	ZiMz
RA	Rest AP	RAAm	RACh	RACp	RAHp	RALu	RAOl	RAPa	RAPi	RAQu	RARd	RASd	RASr	RAZi	RARA	—	RADf	RADi	—	—	—	—	RADz	RAMz
Da	Aripiprazole_LA	DaAm	DaCh	DaCp	DaHp	DaLu	DaOl	DaPa	DaPi	DaQu	DaRd	DaSd	DaSr	DaZi	DaRA	—	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DaMz
Df	Fluphenazine_LA	DfAm	DfCh	DfCp	DfHp	DfLu	DfOl	DfPa	DfPi	DfQu	DfRd	DfSd	DfSr	DfZi	DfRA	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	—	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DfMz
Di	Flupenthixol_LA	DiAm	DiCh	DiCp	DiHp	DiLu	DiOl	DiPa	DiPi	DiQu	DiRd	DiSd	DiSr	DiZi	DiRA	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	—	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DiMz
Dh	Haloperidol_LA	DhAm	DhCh	DhCp	DhHp	DhLu	DhOl	DhPa	DhPi	DhQu	DhRd	DhSd	DhSr	DhZi	DhRA	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	—	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DhMz
Do	Olanzapine_LA	DoAm	DoCh	DoCp	DoHp	DoLu	DoOl	DoPa	DoPi	DoQu	DoRd	DoSd	DoSr	DoZi	DoRA	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	—	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DoMz
Dp	Paliperidone_LA	DpAm	DpCh	DpCp	DpHp	DpLu	DpOl	DpPa	DpPi	DpQu	DpRd	DpSd	DpSr	DpZi	DpRA	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DpDp	DpDr	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DpMz
Dr	Risperidone_LA	DrAm	DrCh	DrCp	DrHp	DrLu	DrOl	DrPa	DrPi	DrQu	DrRd	DrSd	DrSr	DrZi	DrRA	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DrDp	—	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	DrMz
Dz	Zuclopenthixol_LA	DzAm	DzCh	DzCp	DzHp	DzLu	DzOl	DzPa	DzPi	DzQu	DzRd	DzSd	DzSr	DzZi	DzRA	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	[[{{{med99}}}-{{{med99}}}|{{{afk99}}}{{{afk99}}}]]	—	DzMz
Mz	Zuclopenthixol_MA	MzAm	MzCh	MzCp	MzHp	MzLu	MzOl	MzPa	MzPi	MzQu	MzRd	MzSd	MzSr	MzZi	MzRA	—	—	—	—	—	—	—	MzDz	—

LA = long acting, MA = medium acting

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