Fluvoxamine-mianserine
From Psychiatrienet
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Switch medication from fluvoxamine to mianserine.[1] [2]
Stop fluvoxamine - Before day 0: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: reduce fluvoxamine to a dosage of 25 mg/day.
Start mianserine- Day 1: simultaneously start administration of mianserine in a low dosage of 30 mg/day for one week.
- Day 8: stop administration of fluvoxamine and continue administration of mianserine only. If necessary increase dosage of mianserine to normal (60 mg/day).
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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