Fluvoxamine-doxepine
From Psychiatrienet
{{Drugswitch | from = fluvoxamine | to = doxepin | stop =
- Day 1: Decrease dose to 50%
- Day 8: Stop
| start =
- Day 1: start administration of doxepine in a low dosage of 25mg/day.
- Day 8: increase dosage of doxepine to a dosage of 75 mg/day.
| info =
- fluvoxamine slows the metabolism of doxepine via CYP2C19 inhibition.
- Due to CYP inhibition a longer period of time is needed to reach steady state concentration. Please keep in mind when monitoring plasma levels
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[1]
