| stop = * Gradually reduce dosage of agomelatine to a maximum of 25 mg/day. * When a dosage of 25 mg/day is reached , stop administration.{{StopAgomelatine}}

* A wash-out period of one day is necessary.* ''' Day 2: ''' Start administration of fluvoxamine the next day in a normal dosage of 50 mg/day.* ''' After 3 weeks: ''' If necessary, increase dosage of fluvoxamine gradually to 100-300 mg/day

<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102lowlevels}}</ref>