634
edits
Changes
no edit summary
{{Drugswitch
| from = amitriptyline
| to = fluoxetine
| stop =
| start =
* '''Day 1:6 and after''' simultaneously : At approximately 50-25% of the original TCA dosering start administration of fluoxetine in a normal dosage at 100% of 20 mg/daythe target dose.* '''Day 8After 3 weeks:''' stop administration of amitriptyline and continue administration If necessary, gradually increase dosage of fluoxetine.
| info =
* Occurrence Safe target dose fluoxetine = 20 mg* Fluoxetine and norfluoxetine are inhibitors of serotonin syndrome is theoretically possibleCYP2D6 (strong) which metabolizes nortriptyline, so caution is necessary(a metabolite of amitriptyline).}}
