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{{Drugswitch
| from = amitriptyline
| to = fluoxetine
| stop =
| start =
* '''Day 1:6 and after''' simultaneously : At approximately 50-25% of the original TCA dosering start administration of fluoxetine in a normal dosage at 100% of 20 mg/daythe target dose.* '''Day 8After 3 weeks:''' stop administration of amitriptyline and continue administration If necessary, gradually increase dosage of fluoxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose fluoxetine = 20 mg* Fluoxetine is a strong inhibitor and norfluoxetine are inhibitors of CYP2D6, (strong) which metabolizes nortriptyline, (a metabolite of amitriptyline).}}
