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Amitriptyline-fluoxetine

272 bytes removed, 13:53, 2 November 2015
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* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 25-50 mg/day.* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.* '''Day 3:''' reduce dosage of amitriptyline to 10 mg/day.{{stopAmitriptyline}}
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* '''Day 19:''' simultaneously start administration of fluoxetine in a normal dosage of 20 mg/day.* '''Day 816:''' stop administration of amitriptyline and continue administration if necessary, increase dosage of fluoxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Fluoxetine is a strong inhibitor and norfluoxetine are inhibitors of CYP2D6(strong) and CYP3A4 (moderate), which metabolizes metabolize amitriptyline.}}
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