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Amitriptyline-paroxetine

313 bytes removed, 13:54, 2 November 2015
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* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 25-50 mg/day.* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.* '''Day 3:''' reduce dosage of amitriptyline to 10 mg/day.{{stopAmitriptyline}}
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* '''Day 19:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.* '''Day 816:''' stop administration of amitriptyline and continue administration increase dosage of paroxetineif necessary.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes amitriptyline. }}
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