Difference between revisions of "Aripiprazole-Lurasidone"

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| to = Lurasidon
 
| to = Lurasidon
 
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| stop =  
* '''Day 1-7:''' reduce the dose of aripiprazol to 50% of the dose.
+
* '''Day 1-7:''' gradually reduce the dose of aripiprazole to 50% of the dose.
 +
* '''Day 8-14:''' gradually reduce the dose of aripiprazole to 0% of the dose
 
* '''Day 14:''' stop administration of aripiprazol.
 
* '''Day 14:''' stop administration of aripiprazol.
 
| start =  
 
| start =  

Revision as of 13:16, 5 March 2015

Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole
Lurasidone
Type Antipsychotic
Group Atypical AP
links
Medscape Lurasidone
PubMed Lurasidone
Kompas (Dutch) Lurasidone
Wikipedia Lurasidone

Switch medication from Aripiprazole to Lurasidon.[1] [2]

Nietinrijdenbord.png Stop Aripiprazole
  • Day 1-7: gradually reduce the dose of aripiprazole to 50% of the dose.
  • Day 8-14: gradually reduce the dose of aripiprazole to 0% of the dose
  • Day 14: stop administration of aripiprazol.
Eenrichtingbord.png Start Lurasidon
  • Day 1-7: start administration of lurasidon in a dose of 40 mg/day.
  • Day 8-14: increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  • It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. [4]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
  4. McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
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