| to = amitriptyline
| stop =
* Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. * When a dosage of 150 mg/day is reached, stop administration.{{StopBupropion}}
| start =
* '''Day 1-3:''' start administration of amitriptyline the next day in a low dosage of 25 mg/day.{{Inc25p3d2}}* '''Day 4:''' increase dosage of amitriptyline to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
| info =
* Bupropion slows the metabolism of amitriptyline by via CYP2D6.* Caution is necessary at the start of administration of amitriptyline. * {{RiskSeizureBupropionTCA}}}}
