| to = imipramine
| stop =
* '''Before day 1:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.* '''Day 1:''' Stop administration of bupropion{{stopBupropion}}| start = * '''Day 1-3:''' start administration of imipramine the next day in a low dosage of 25 mg25mg/day.* '''Day 48:''' increase dosage of imipramine to a dosage of 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
| info =
* Bupropion slows the metabolism of imipramine via CYP2D6.
* Caution is necessary at the start of administration of imipramine.
* {{RiskSeizureBupropionTCA}}
* {{TCAplasmalevelmonitoring}}
}}
