Changes

* '''Day 1-3:''' start administration of maprotiline the next day in a low dosage of 25 mg/day.* '''Day 48:''' increase dosage administration of maprotiline to a dosage of 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.

* Bupropion slows the metabolism of maprotiline by via CYP2D6.* Caution is necessary at the start of administration of maprotiline. {{RiskSeizureBupropionTCA}}* {{TCAplasmalevelmonitoring}}}}