Switch medication from bupropion to moclobemide.
- Before day 1: gradually reduce dosage of bupropion to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
- Day 1: reduce dosage of bupropion to 150 mg/day.
- Day 8: stop administration of bupropion.
- Day 1-7: wash-out period of one week is necessary.
- Day 8: start moclobemide with 150 mg/day.
- Day 12: increase moclobemide to 300 mg/day.
- Day 15: if necessary, increase moclobemide to 600 mg/day.
- Occurrence of the serotonin syndrome is possible without wash-out period.
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